10mg/1ml Chlorpheniramine Injection / Chlorphenamine Maleate
Product : Chlorpheniramine Injection
Specification : 10mg/1ml
Standard : BP, USP
Packing : 10 x 10amps/box
Chlorpheniramine is a histamine H1 antagonist used in allergic
reactions, hay fever, rhinitis, urticaria, and asthma. It has also
been used in veterinary applications. One of the most widely used
of the classical antihistaminics, it generally causes less
drowsiness and sedation than promethazine.
For the treatment of rhinitis, urticaria, allergy, common cold,
asthma and hay fever.
In allergic reactions an allergen interacts with and cross-links
surface IgE antibodies on mast cells and basophils. Once the mast
cell-antibody-antigen complex is formed, a complex series of events
occurs that eventually leads to cell-degranulation and the release
of histamine (and other chemical mediators) from the mast cell or
basophil. Once released, histamine can react with local or
widespread tissues through histamine receptors. Histamine, acting
on H1-receptors, produces pruritis, vasodilatation, hypotension,
flushing, headache, tachycardia, and bronchoconstriction. Histamine
also increases vascular permeability and potentiates pain.
Chlorpheniramine, is a histamine H1 antagonist (or more correctly,
an inverse histamine agonist) of the alkylamine class. It competes
with histamine for the normal H1-receptor sites on effector cells
of the gastrointestinal tract, blood vessels and respiratory tract.
It provides effective, temporary relief of sneezing, watery and
itchy eyes, and runny nose due to hay fever and other upper
Mechanism of action
Chlorpheniramine binds to the histamine H1 receptor. This blocks
the action of endogenous histamine, which subsequently leads to
temporary relief of the negative symptoms brought on by histamine.